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KMID : 0363619990200010161
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Journal of Korean Oriental Medicine
1999 Volume.20 No. 1 p.161 ~ p.171
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Effects of Complex formula including Korea Red Ginseng (CKRG) on Brain Ischemia Induced by Occlusion of Middle Cerebral Artery
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Oh Sang Jin
Park Il-Hyun
Kim Sung-Hoon
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Abstract
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This study was performed to investigate the effect of complex formula(CKRG) consisting of Panax ginseng Radix rubra Koreana. Ganoderma, Cinnamomi Cortex, Glycyrrhizae Radix and Laminariae Thallus on brain ischemia and injury such as KCN-induced brain injury, forced brain ischemia, pulmonary thrombosis. The results were summarized as follows: 1. CKRG extracts showed a decrease of the duration of KCN-induced coma and showcd an increase in life expectancy. 2. CKRG extracts showed a decrease of neurologic grade in hind limb but did not affect neurologic grades in fore limb. Also. CKRG extracts showed a significant decrease of brain ischemic area and edema in MCA occlusion, 3. CKRG extracts showed a protective effect on pulmonary thrombosis induced by collagen and epinephrine. These data suggested that CKRG extracts could be applied to the protection of brain ischemia and injury.
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KEYWORD
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CKRG, brain ischemia, KCN, MCA
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